Discovery of new chemical leads for prostaglandin D2 receptor antagonists

Kazuhiko Torisu; Kaoru Kobayashi; Maki Iwahashi; Hiromu Egashira; Yoshihiko Nakai; Yutaka Okada; Fumio Nanbu; Shuichi Ohuchida; Hisao Nakai; Masaaki Toda

doi:10.1016/j.bmcl.2004.06.006

Discovery of new chemical leads for prostaglandin D2 receptor antagonists

Bioorg Med Chem Lett. 2004 Sep 6;14(17):4557-62. doi: 10.1016/j.bmcl.2004.06.006.

Authors

Kazuhiko Torisu¹, Kaoru Kobayashi, Maki Iwahashi, Hiromu Egashira, Yoshihiko Nakai, Yutaka Okada, Fumio Nanbu, Shuichi Ohuchida, Hisao Nakai, Masaaki Toda

Affiliation

¹ Minase Research Institute, Ono Pharmaceutical Co., Ltd, Shimamoto, Mishima, Osaka 618-8585, Japan. torisu@ono.co.jp

PMID: 15357992
DOI: 10.1016/j.bmcl.2004.06.006

Abstract

A series of Indomethacin analogs were synthesized and biologically evaluated. Among the compounds tested, N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid 2 was discovered as a new chemical lead for a prostaglandin D2 (PGD2) receptor antagonist. Structure-activity relationship data are also presented.

MeSH terms

Animals
CHO Cells
Cricetinae
Mice
Prostaglandin Antagonists / chemistry*
Prostaglandin Antagonists / metabolism
Receptors, Immunologic / antagonists & inhibitors*
Receptors, Immunologic / metabolism
Receptors, Prostaglandin / antagonists & inhibitors*
Receptors, Prostaglandin / metabolism

Substances

Prostaglandin Antagonists
Receptors, Immunologic
Receptors, Prostaglandin
prostaglandin D2 receptor